Seviteronel R enantiomer (VT-464 (R enantiomer)) (Synonyms: VT-464 (R enantiomer)) |
| رقم الكتالوجGC33911 |
Seviteronel R enantiomer (VT-464 (R enantiomer)) (VT-464 R enantiomer) هو R enantiomer لـ Seviteronel (VT-464) ، وهو مثبط قوي لياز CYP17 (h-Lyase IC50 = 69 نانومتر) ؛ Seviteronel (VT-464) R enantiomer' ؛ نشاط غير معروف.
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Cas No.: 1375603-38-5
Sample solution is provided at 25 µL, 10mM.
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Seviteronel (VT-464) R enantiomer is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.
[1]. Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7. [2]. Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1
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