SHIN1 (Synonyms: RZ2994) |
| رقم الكتالوجGC32773 |
SHIN1 (RZ-2994) هو مثبط لإنزيم السيرين هايدروكسي مثيل ترانسفيراز 1 و 2 (SHMT1/2) البشرية، بتراكيز IC50 قدرها 5 و13 نانومتر على التوالي في اختبار in vitro.
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Cas No.: 2146095-85-2
Sample solution is provided at 25 µL, 10mM.
SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
SHIN1 inhibits human SHIN1 SHMT1/2 with IC50s of 5 and 13 nM, respectively in an in vitro assay. SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells with an IC50 of 10 nM. SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 is particularly active against B-cell malignancies. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates[1].
[1]. Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
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