SKA-111 |
| رقم الكتالوجGC70205 |
SKA-111 هو منشط انتقائي من فانيل البوتاسيوم KCa 3.1، يثير فرط استقطاب غشاء KCa 3.1 في الخلية البطانية للخنازير.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1369170-24-0
Sample solution is provided at 25 µL, 10mM.
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SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].
SKA-111 (1 μM for cardiac perfusion) improves Bradykinin -induced coronary dilations in the isolated rat heart[1].
References:
[1]. Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.
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