SKA-111 |
رقم الكتالوجGC70205 |
SKA-111 هو منشط انتقائي من فانيل البوتاسيوم KCa 3.1، يثير فرط استقطاب غشاء KCa 3.1 في الخلية البطانية للخنازير.
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Cas No.: 1369170-24-0
Sample solution is provided at 25 µL, 10mM.
SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].
SKA-111 (1 μM for cardiac perfusion) improves Bradykinin -induced coronary dilations in the isolated rat heart[1].
References:
[1]. Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.
Average Rating: 5
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