SMS2-IN-2 |
| رقم الكتالوجGC65300 |
SMS2-IN-2 هو مثبط قوي ، انتقائي للغاية وفعال عن طريق الفم سينثاز 2 (SMS2) ، مع IC50s من 100 نانومتر و 56 ميكرومتر ل SMS2 و SMS1 ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2241838-28-6
Sample solution is provided at 25 µL, 10mM.
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SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].
SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice[1].
[1]. Mo M, et al. Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem. 2018 Sep 27;61(18):8241-8254.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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