SPC5001 |
| رقم الكتالوجGC71043 |
SPC5001 هو نوع من العقاقير oligodeoxynucleotide ( ASO ) تعديل الحمض النووي حبس ( LNA ) مكملة لحقوق pcsk9 ( proprotein الانفرتيز العصوية الرقيقة البروتيني / kexin 9 ) مرنا .
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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SPC5001 (0.16-40 µM; 72 h) induces the downregulation of PCSK9 mRNA targets but cytotoxicity is not observed at any concentration in 2D human renal proximal tubule epithelial cells (HRPTEC) cultures[1].
SPC5001 (5 µM; 48 h or 20 d) downregulates PCSK9 mRNA in chip-cultured HRPTEC, with 74.1% and 93.7% for 48 h and 20 days, respectively[1].
SPC5001 (5 µM; 20 d) induces cytotoxicity and increases perfusate levels of biomarkers KIM-1, NGAL, clusterin, osteopontin and VEGF in chip-cultured HRPTEC[1].
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