Spiromesifen |
| رقم الكتالوجGC48093 |
An insecticide and acaricide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 283594-90-1
Sample solution is provided at 25 µL, 10mM.
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Spiromesifen is an insecticide and acaricide that reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase.1,2 It inhibits chitinase from Egyptian cotton leafworm (S. littoralis) larvae (IC50s = 0.60 and 0.72 μM for enzyme isolated from lab and field strains, respectively).3 It induces toxicity in whitefly (T. vaporariorum) nymphs (LC50 = 0.61 mg/L), spider mite (T. cinnabarinus) eggs (LC50 = 0.16 mg/kg), and second instar larvae of S. littoralis lab and field strains (LC50s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application).1,2,3 Spiromesifen (600 mg/kg) also induces 50, 60, and 70% mortality in the Lepidoptera pests H. armigera, O. nubilalis, and P. xylostella, respectively, and induces 100% mortality in M. separata when used at a dose of 100 mg/kg.2 It induces toxicity in D. magna (EC50 = >0.092 mg a.s./L) and the fish species O. mykiss and L. macrochirus (LC50s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD50 = >2,000 mg/kg).4 Spiromesifen also inhibits the human GST isozyme GSTA1-1 (IC50 = 12.1 μM).5
1.Karatolos, N., Williamson, M.S., Denholm, I., et al.Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid replacement in its target enzyme acetyl-coenzyme A carboxylaseInsect Mol. Biol.21(3)327-334(2012) 2.Liu, Z., Lei, Q., Li, Y., et al.Design, synthesis, structure, and acaricidal/insecticidal activity of novel spirocyclic tetronic acid derivatives containing an oxalyl moietyJ. Agric. Food Chem.59(23)12543-12549(2011) 3.Ismail, S.M., and Morshedy, M.Evaluation of some environmentally safe cemicals against Spodoptera littoralisAlexandria Sci. Exch. J.30(1)121-127(2009) 4.Authority, E.F.S.Conclusion on the peer review of the pesticide risk assessment of the active substance spiromesifenEFSA J.10(10)2879(2012) 5.Chronopoulou, E.G., Papageorgiou, A.C., Markoglou, A., et al.Inhibition of human glutathione transferases by pesticides: Development of a simple analytical assay for the quantification of pesticides in waterJ. Mol. Catal. B: Enzymatic8143-51(2012)
| Cas No. | 283594-90-1 | SDF | |
| Canonical SMILES | CC1=C(C2=C(OC(CC(C)(C)C)=O)C3(CCCC3)OC2=O)C(C)=CC(C)=C1 | ||
| Formula | C23H30O4 | M.Wt | 370.5 |
| الذوبان | DMSO : 125 mg/mL (337.40 mM; ultrasonic and warming and heat to 60°C) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6991 mL | 13.4953 mL | 26.9906 mL |
| 5 mM | 0.5398 mL | 2.6991 mL | 5.3981 mL |
| 10 mM | 0.2699 mL | 1.3495 mL | 2.6991 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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