SSR 180711 hydrochloride |
رقم الكتالوجGC50202 |
SSR 180711 هيدروكلوريد هو ناهض جزئي فعال عن طريق الفم وانتقائي وقابل للانعكاس α7 مستقبلات النيكوتين (n-AChRs).
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Cas No.: 446031-79-4
Sample solution is provided at 25 µL, 10mM.
Partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.
Jones et al (2014) Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 231 673 PMID:24057763 |Pichat et al (2007) SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 17 PMID:16936709
Average Rating: 5
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