الصفحة الرئيسية>>Signaling Pathways>> JAK/STAT Signaling>> STAT>>STAT6-IN-1

STAT6-IN-1

رقم الكتالوجGC71018

STAT6-IN-1 (مركب 19a) هو مثبط STAT6 مع تقارب كبير لنطاق SH2 من STAT6 (IC50=0.028 µM).

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STAT6-IN-1 التركيب الكيميائي

Cas No.: 1637532-68-3

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
1134٫00
متوفر
1 mg
329٫00
متوفر
5 mg
691٫00
متوفر

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مراجعات العميل

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  • GlpBio Citations

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
STAT6-IN-1 (compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer.

References:
[1]. Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58(22):8970-84.
[2]. John S, et al. Stat6 inhibitors. Patent WO2014182928A2.

مراجعات

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