Sulfisoxazole (Synonyms: NSC 13120, NSC 33807, NSC 38588, NSC 683536, Sulfafurazole) |
| رقم الكتالوجGC12231 |
Sulfisoxazole (Sulfafurazole) هو مضاد لمستقبلات الإندوثيلين بقيم IC50 0.60 ميكرومتر و 22 ميكرومتر ضد مستقبلات الإندوثيلين A ومستقبلات الإندوثيلين B ، على التوالي
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Cas No.: 127-69-5
Sample solution is provided at 25 µL, 10mM.
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Sulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent.Target: Antibacterial; Endothelin ReceptorThe sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria [2].
References:
[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.
[2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998
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