T-26c |
| رقم الكتالوجGC31862 |
يعتبر T-26c مثبطًا عالي الفعالية وانتقائيًا للبروتيناز المعدني 13 (MMP-13) مع IC50 من 6.75 بيكو مولار وأكثر من 2600 ضعف انتقائية على الإنزيمات المعدنية الأخرى ذات الصلة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 869296-13-9
Sample solution is provided at 25 µL, 10mM.
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T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].
T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage[1].
[1]. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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