Taldefgrobep alfa |
| رقم الكتالوجGC72401 |
Taldefgrobep alfa (BMS 986089 ؛ RG 6206 ؛ RO 7239361) هو جسم مضاد مثبط قوي يستهدف الميوستاتين البشري.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1580555-26-5
Sample solution is provided at 25 µL, 10mM.
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Taldefgrobep alfa (2 mg/kg; iv or sc; single dose) has rapid plasma clearance after intravenous administration in mice, but slow absorption (Tmax=24 h) after subcutaneous administration with Cmax=15.4 mg/mL and bioavailability (F)=84%[1].
References:
[1]. Zhu Y, et al. LC-MS/MS multiplexed assay for the quantitation of a therapeutic protein BMS-986089 and the target protein Myostatin. Bioanalysis. 2016 Feb;8(3):193-204.
[2]. Straus M. 2023 Pipeline Report: Testing the Limits[J]. Pharmaceutical Executive, 2022, 42(12).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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