Tariquidar dihydrochloride (Synonyms: XR9576 dihydrochloride) |
| رقم الكتالوجGC50254 |
ثنائي هيدروكلوريد Tar Liquidar (XR9576 ثنائي هيدروكلوريد) هو مثبط قوي ومحدد لبروتين P-glycoprotein (P-gp) مع التقارب العالي (Kd = 5.1 نانومتر).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1992047-62-7
Sample solution is provided at 25 µL, 10mM.
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Potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin and mitoxantrone in vitro.
Kannan et al (2011) The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem.Neurosci. 2 82 PMID:22778859 |Loo et al (2015) Mapping the binding site of the inhibitor Tariquidar that stabilizes the first transmembrane domain of P-glycoprotein. J.Biol.Chem. 290 29389 PMID:26507655
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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