Tau-aggregation and neuroinflammation-IN-1 |
| رقم الكتالوجGC70951 |
Tau-aggregation and neuroinflammation-IN-1 هو تجميع تاو قوي و مثبط للإلتهاب العصبي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2175953-98-5
Sample solution is provided at 25 µL, 10mM.
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Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM, and exerts no significant hepatotoxicity in LO2 cells at high concentrations, also exerts no effect on BV2 cell viability at 20 μM[1].
Tau-aggregation and neuroinflammation-IN-1 (2.5, 5 and 10 μM; 24 hours) retains the anti-inflammatory activity of sodium usnate and inhibits NO release rate by 41% in LPS-stimulated BV2 cells at 10 μM[1].
Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; for 14 days) leads to a substantial improvement of the conventional reference spatial memory and cognitive abilities of OA-induced rats[1].
References:
[1]. Shi CJ, Peng W, Zhao JH, et al. Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors. Eur J Med Chem. 2020;187:111961.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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