TC JL 37 |
| رقم الكتالوجGC50350 |
TC JL 37 هو مثبط TYK2 قوي وانتقائي ومتوفر بيولوجيًا عن طريق الفم مع Ki 1.6 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1258294-34-6
Sample solution is provided at 25 µL, 10mM.
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Potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.
Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID:23668484
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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