TCS 5861528 (Synonyms: TCS 5861528) |
| رقم الكتالوجGC11185 |
TCS 5861528 (TCS 5861528) هو مضاد قوي لقناة TRPA1 الذي يعادي استجابات TRPA1 ذات الأليل المشابه و 4-HNE ، مع قيم IC50 14.3 μ ؛ M و 18.7 μ ؛ M ، على التوالي.
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Cas No.: 332117-28-9
Sample solution is provided at 25 µL, 10mM.
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Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).
References:
[1]. Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54.
[2]. Wei H, et al. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 2010 Mar;58(3):578-84.
[3]. Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.
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