TD-0212 TFA |
| رقم الكتالوجGC38856 |
TD-0212 TFA هو مُضاد لمستقبلات الأنجيوتنسين الثاني من النوع الأول (AT1) ومضاد للنيبريليسين (NEP) ، مع pKi من 8.9 لـ AT1 و pIC50 من 9.2 لـ NEP
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Cas No.: 1073549-11-7
Sample solution is provided at 25 µL, 10mM.
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TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].
TD-0212 provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition[1].
TD-0212 produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and -independent hypertension[1].
[1]. McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS Med Chem Lett. 2018 Dec 3;10(1):86-91.
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