TG2-179-1 |
| رقم الكتالوجGC91039 |
مثبط BAP1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1135023-19-6
Sample solution is provided at 25 µL, 10mM.
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TG2-179-1 is an inhibitor of BRCA1-associated protein 1 (BAP1).1 It inhibits the deubiquitinase activity of BAP1 in a cell-free assay when used at concentrations ranging from 25 µM to 1.5 mM. TG2-179-1 is cytotoxic against a panel of eight colon cancer cell lines (IC50s = 4.48-7.52 µM). In vivo, TG2-179-1 (10 and 30 mg/kg) reduces tumor volume in an HCT116 colon cancer mouse xenograft model.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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