TMX-4100 |
| رقم الكتالوجGC63520 |
TMX-4100 عبارة عن مزيل فوسفوديستراز 6D انتقائي (PDE6D)يُظهر TMX-4100 تفضيلًا عاليًا للتدهور لـ PDE6D مع قيم DC50 أقل من 200 نانومتر في خلايا MOLT4 و Jurkat و MM.1Sيمكن استخدام TMX-4100 في البحث عن المايلوما المتعددة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2367619-63-2
Sample solution is provided at 25 µL, 10mM.
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TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1].
TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells[1].TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216[1].TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells)[1].
[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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