Tr-PEG2-OH |
| رقم الكتالوجGC66952 |
Tr-PEG2-OH عبارة عن رابط PROTAC قائم على PEG يمكن استخدامه في تركيب PROTACs. Tr-PEG2-OH هو أيضًا رابط PEG ADC مكون من وحدتين غير قابل للكسر يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 105589-77-3
Sample solution is provided at 25 µL, 10mM.
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Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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