Trandolaprilat (hydrate) (Synonyms: RU 44403) |
| رقم الكتالوجGC46233 |
Trandolaprilat (الهيدرات) هو مثبط قوي لإنزيم تحويل الأنجيوتنسين (ACE).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 951393-55-8
Sample solution is provided at 25 µL, 10mM.
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Trandolaprilat is an angiotensin-converting enzyme (ACE) inhibitor.[1] It inhibits angiotensin I-induced contraction in isolated rat thoracic aorta (IC50 = 6.9 nM) and potentiates bradykinin-induced contraction in isolated guinea pig ileum with a 50% augmentation concentration (AC50) value of 2.7 nM. Trandolaprilat induces relaxation of norepinephrine- or potassium chloride-precontracted isolated rat thoracic aorta with intact endothelium in a concentration-dependent manner. Trandolaprilat inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 9.9 and 7.2 μg/kg, respectively) and potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg).[2]
Reference:
[1]. Sekiguchi, N., Ishii, Y., Fujikura, H., et al. Pharmacological action of (-)-(2S,3aR,7aS)-1-[(S)-N-[(S)-1-carbonyl-3-phenylpropyl]alanyl]hexahydro-2-indolinecarboxylic acid (trandolaprilat) in isolated smooth muscle preparations. Gen. Pharmacol. 24(3), 585-590 (1993).
[2]. Brown, N.L., Badel, M.-Y., Benzoni, F., et al. Angiotensin-converting enzyme inhibition, anti-hypertensive activity and hemodynamic profile of trandolapril (RU 44570). Eur. J. Pharmacol. 148(1), 79-91 (1988).
| Cas No. | 951393-55-8 | SDF | |
| المرادفات | RU 44403 | ||
| Chemical Name | (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic acid, monohydrate | ||
| Canonical SMILES | O=C(O)[C@@H](N[C@@H](C)C(N1[C@](CCCC2)([H])[C@@]2([H])C[C@H]1C(O)=O)=O)CCC3=CC=CC=C3.O | ||
| Formula | C22H30N2O5 • H2O | M.Wt | 420.5 |
| الذوبان | DMSO: slightly soluble,Methanol: slightly, heated, sonicated | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3781 mL | 11.8906 mL | 23.7812 mL |
| 5 mM | 0.4756 mL | 2.3781 mL | 4.7562 mL |
| 10 mM | 0.2378 mL | 1.1891 mL | 2.3781 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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