Tyrosylleucine TFA (Synonyms: Tyr-Leu TFA) |
| رقم الكتالوجGC63245 |
Tyrosylleucine (Tyr-Leu، YL) TFA ، ثنائي الببتيد النشط عن طريق الفم ، يُظهر نشاطًا شبيهًا بمضادات الاكتئاب
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Cas No.: 66852-01-5
Sample solution is provided at 25 µL, 10mM.
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Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Tyrosylleucine (Tyr-Leu, YL) increases the amount of cells expressing c-Fos, a marker for neuronal activity, in the dentate gyrus of the hippocampus[1].
Tyrosylleucine (Tyr-Leu, YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1 mg/kg, i.p.)[2].
[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.
[2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.
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