UKI-1 (UKI-1C) (Synonyms: UKI-1C) |
| رقم الكتالوجGC32119 |
UKI-1 (UKI-1C) (UKI-1 (UKI-1C) C) هو مثبط فعال للبلازمينوجين من نوع urokinase (uPA) مع Ki من 0.41 μ ؛ M. UKI-1 (UKI-1C) هو أيضًا من مثبطات الأنزيم البروتيني السيرين منخفض الوزن الجزيئي. UKI-1 (UKI-1C) هو عامل فعال مضاد للقسط ويثبط القدرة الغازية للخلايا السرطانية.
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Cas No.: 220355-63-5
Sample solution is provided at 25 µL, 10mM.
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UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator system. It can also inhibits the invasive capacity of carcinoma cells. (Ki=0.41 μM)In vitro : A decrease of tumor cell invasion by up to 50% was achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa after treatment with UK1.
[1]. Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24. [2]. Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75.
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