Urocortin (human) |
| رقم الكتالوجGC17432 |
يعمل Urocortin (بشري) ، وهو ببتيد عصبي 40-aa ، بمثابة ناهض انتقائي لمستقبل CRF2 الداخلي ، مع Kis من 0.4 و 0.3 و 0.5 نانومتر لـ hCRF1 و rCRF2α و mCRF2β ، على التوالي.
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Cas No.: 176591-49-4
Sample solution is provided at 25 µL, 10mM.
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Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively.
Urocortin, human is a selective agonist of CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α and mouse CRF2β receptors in cell assay, respectively[1].
Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].
References:
[1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.
[2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.
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