UT-B-IN-1 |
| رقم الكتالوجGC70608 |
UT-B-IN-1 (UTBINH-14) هو مثبط قابل للعكس، تنافسي وانتقائي لناقل اليوريا B (UT-B) مع قيم IC50 من 10 و 25 نانومتر بالنسبة للبشر والفئران UT-B على التوالي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 892742-76-6
Sample solution is provided at 25 µL, 10mM.
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UT-B-IN-1 (1-1000 nM) inhibits urea efflux in erythrocytes preloaded with urea with an IC50 value of 26.7 nM[1].
UT-B-IN-1 inhibits water transport in AQP1-null erythrocytes[1].
UT-B-IN-1 (0-10 μM;24 h) shows no cytotoxicity to MDCK cells[1].
UT-B-IN-1 (300 μg; i.p., once) increases urine output and reduces urine osmolality in mice with free access to water and food[1].
References:
[1]. Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20.
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