الصفحة الرئيسية>>Signaling Pathways>> Ubiquitination/ Proteasome>> Autophagy>>Vandetanib (ZD6474)

Vandetanib (ZD6474) (Synonyms: ZD6474)

رقم الكتالوجGC15022

Vandetanib (ZD6474) (D6474) هو مثبط قوي ونشط عن طريق الفم لنشاط التيروزين كيناز VEGFR2 / KDR (IC50 = 40 نانومتر). يحتوي Vandetanib (ZD6474) أيضًا على نشاط مقابل نشاط التيروزين كيناز لـ VEGFR3 / FLT4 (IC50 = 110 نانومتر) و EGFR / HER1 (IC50 = 500 نانومتر).

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Vandetanib (ZD6474) التركيب الكيميائي

Cas No.: 443913-73-3

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
62٫00
متوفر
25mg
54٫00
متوفر
100mg
181٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

ZD6474 is a dual inhibitor of VEGFR-2 and EGFR with IC50 values of 40 nM and 500 nM, respectively [1].

ZD6474 showed potent inhibition activities against recombinant VEGFR-2 and EGFR in the in vitro assays. The inhibition of VEGFR-2 was 2.7-fold more potent than that of VEGFR-3 (Flt-4) kinase and 40-fold more potent than that of VEGFR-1. In human umbilical vein endothelial cells, treatment of ZD6474 resulted in significant inhibition of cell proliferation stimulated by VEGF and EGF with IC50 values of 60 and 170 nM, respectively. Through inhibiting the kinase activity of EGFR, ZD6474 can inhibit cell growth of various cancer cell lines, including lung, ovarian, breast and colon cancers. Besides that, ZD6474 administration inhibited tumor growth in a dose-dependent manner in many tumor xenograft models.

References:
[1] Ryan A J, Wedge S R. ZD6474–a novel inhibitor of VEGFR and EGFR tyrosine kinase activity[J]. British journal of cancer, 2005, 92: S6-S13.

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