Viltolarsen sodium |
| رقم الكتالوجGC70671 |
Viltolarsen sodium هو phosphorodiamidate مورفولينو مضاد حس الأوليغنوكليوتيد.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Viltolarsen (NS-065/NCNP-01; 2 days) sodium induces exon 53 skipping in cells from a DMD model with a deletion of exons 45-52 with an EC50 value of 0.63 μM and in cells with a deletion of exons 48-52 with an EC50 value of 2.3 μM[2].
Viltolarsen (10 μM; 3 days) sodium causes the dystrophin protein expression in cells from a DMD model[2].
References:
[1]. Sohita Dhillon. Viltolarsen: First Approval. Drugs. 2020 Jul;80(10):1027-1031.
[2]. Naoki Watanabe, et al. NS-065/NCNP-01: An Antisense Oligonucleotide for Potential Treatment of Exon 53 Skipping in Duchenne Muscular Dystrophy. Mol Ther Nucleic Acids. 2018 Dec 7:13:442-449.
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