Visilizumab |
| رقم الكتالوجGC72365 |
مضاد CD3E المأشوب Visilizumab (بالإنجليزية: Anti-Human CD3E) هو جسم مضاد من نوع IgG2 أحادي النسل ومتحول إلى إنساني مرتبط بمستقبلات منخفضة Fc.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 219716-33-3
Sample solution is provided at 25 µL, 10mM.
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Visilizumab induces dose- and time-dependent apoptosis of lamina propria T cells. Visilizumab-induces apoptosis of lamina propria T cells is dependent on caspase 3 and 8, but not caspase 9 activation and does not involve the Fas/FasL pathway[1].
References:
[1]. Qi T Yu, et al. Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways. Clin Immunol. 2008 Jun;127(3):322-9.
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