VU0360172 |
| رقم الكتالوجGC64513 |
VU0360172 عبارة عن مُعدِّل خيفي إيجابي قوي وانتقائي لمستقبل mGlu5 بقيمة EC50 تبلغ 16 نانومتر و Ki تبلغ 195 نانومتر ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1310012-12-4
Sample solution is provided at 25 µL, 10mM.
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VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.
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