XY028-133 |
| رقم الكتالوجGC62701 |
XY028-133 (المثال 14) عبارة عن جهاز CDK4 / 6 قائم على PROTAC مع نشاط مضاد للورم ، والذي يتكون من روابط لـ von Hippel-Lindau و CDK
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Cas No.: 2229974-73-4
Sample solution is provided at 25 µL, 10mM.
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XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity[1].
XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].
[1]. JIN, Jian, et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.
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