YAP-TEAD-IN-1 TFA |
| رقم الكتالوجGC39461 |
YAP-TEAD-IN-1 TFA هو مثبط ببتيد قوي وتنافسي لتفاعل YAP-TEAD (IC50 = 25 نانومتر)YAP-TEAD-IN-1 TFA عبارة عن ببتيد 17mer ويظهر تقارب ارتباط أعلى بـ TEAD1 (Kd = 15 نانومتر) من YAP (50-171) (Kd = 40 نانومتر)
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Cas No.: 1659305-79-9
Sample solution is provided at 25 µL, 10mM.
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YAP-TEAD TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].
[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.
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