yGsy2p-IN-H23 |
رقم الكتالوجGC61406 |
yGsy2p-IN-H23 هو مثبط فعال والأول في فئته لخميرة الجليكوجين سينثاز 2 (yGsy2p) مع IC50 من 875 ميكرومتر للجليكوجين البشري سينثيز 1 (hGYS1)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1269190-98-8
Sample solution is provided at 25 µL, 10mM.
yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs)[1].
yGsy2p-IN-H23 (compound H23) has IC50 values against either hGYS1δ634S8,11N or wild-type hGYS1 were 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1].
[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.
Average Rating: 5
(Based on Reviews and 23 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *