ZD-0892 |
| رقم الكتالوجGC32628 |
ZD-0892 هو مثبط انتقائي وقوي لإيلاستاز العدلات مع Kis من 6.7 و 200 نانومتر للإيلاستاز العدلات البشرية والإيلاستاز البنكرياس الخنازير ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 171964-73-1
Sample solution is provided at 25 µL, 10mM.
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ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis[1]. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats[2].
[1]. Lee JK, et al. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Nat Med. 1998 Dec;4(12):1383-91. [2]. Cowan KN, et al. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med. 2000 Jun;6(6):698-702.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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