Artemether-d3 (Synonyms: (+)-Artemether-d3) |
| Catalog No.GC46881 |
An internal standard for the quantification of artemether
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 93787-85-0
Sample solution is provided at 25 µL, 10mM.
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Artemether-d3 is intended for use as an internal standard for the quantification of artemether by GC- or LC-MS. Artemether is an antiparasitic agent and a derivative of artemisinin .1 It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively).2 Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively.3 It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg.1 Formulations containing artemether have been used in the treatment of malaria.
1.Xiao, S.H., and Catto, B.A.In vitro and in vivo studies of the effect of artemether on Schistosoma mansoniAntimicrob. Agents Chemother.33(9)1557-1562(1989) 2.Pillai, D.R., Lau, R., Khairnar, K., et al.Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infectionsMalar. J.11131(2012) 3.Shmuklarsky, M.J., Klayman, D.L., Milhous, W.K., et al.Comparison of β-artemether and β-arteether against malaria parasites in vitro and in vivoAm. J. Trop. Med. Hyg.48(3)377-384(1993)
| Cas No. | 93787-85-0 | SDF | |
| Synonyms | (+)-Artemether-d3 | ||
| Canonical SMILES | [H][C@]12[C@@H](C)[C@@H](OC([2H])([2H])[2H])O[C@@]3([H])[C@@]1(OO4)[C@](CC[C@]4(C)O3)([H])[C@H](C)CC2 | ||
| Formula | C16H23D3O5 | M.Wt | 301.4 |
| Solubility | DMSO : 100 mg/mL (331.80 mM; Need ultrasonic); H2O : 0.1 mg/mL (0.33 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3179 mL | 16.5893 mL | 33.1785 mL |
| 5 mM | 0.6636 mL | 3.3179 mL | 6.6357 mL |
| 10 mM | 0.3318 mL | 1.6589 mL | 3.3179 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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