ASO 556089 sodium |
| Catalog No.GC71044 |
ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ .
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ASO 556089 (0.16-40 µM; 72 h) targeting PCSK9 and MALAT1 in 2D HRPTEC cultures[1].
ASO 556089 (1 and 10µM; 48 h) causes target transcriptional downregulation in HRTEC cultured on chip[1].
ASO 556089 (0.31-5 μM; 48 h) inhibits MALAT1 gene expression in 2D HRPTEC culture[1].
ASO 556089 (40 µM; 72 h) does not cause cytotoxicity[1].
References:
[1]. Nieskens TTG, et al. Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip. Arch Toxicol. 2021 Jun;95(6):2123-2136.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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