Bis-PEG3-acid |
Catalog No.GC62672 |
Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
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Cas No.: 96517-92-9
Sample solution is provided at 25 µL, 10mM.
Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.
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