Canrenoate potassium (Synonyms: Aldadiene potassium; SC-14266) |
| Catalog No.GC61982 |
Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist.
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Cas No.: 2181/4/6
Sample solution is provided at 25 µL, 10mM.
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Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3].
Potassium canrenoate has been shown to cause in rats a dose-dependent increase in myelogenous leukemia and statistically significant increases in malignant tumor of the liver, thyroid, brain and mammary gland[2][3].Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat[4].
[1]. Iqbal J, Andrew R, et al. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014;99(3):915-922.
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