1,2-Dioleoyl-sn-glycero-3-PC (Synonyms: sn3Dioleoyllecithin, 1,2Dioleoylsnglycero3Phosphocholine, 1,2DOPC, PDD 111) |
| Catalog No.GC41814 |
1,2-Dioleoyl-sn-glycero-3-PC (DOPC) is an unsaturated phospholipid containing two oleic acid chains (18:1) and is commonly used for the formation of micelles, liposomes, and other types of artificial membranes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4235-95-4
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleoyl-sn-glycero-3-PC (DOPC) is an unsaturated phospholipid containing two oleic acid chains (18:1) and is commonly used for the formation of micelles, liposomes, and other types of artificial membranes[1]. 1,2-Dioleoyl-sn-glycero-3-PC can incorporate purified proteins from dodecyl-β-D-maltopyranoside (DDM) to form mixed PC-DDM micelles [2]. It can form stable phospholipid bilayers, which are utilized to study structural changes in multi-component biological membranes under various physiological conditions [3]. 1,2-Dioleoyl-sn-glycero-3-PC is also used for the encapsulation of drugs, proteins, and nucleic acids [4]. As a neutral lipid, 1,2-Dioleoyl-sn-glycero-3-PC has minimal impact on cell signaling and can be used as a control to distinguish the specific effects of phosphatidic acid (PA) on Hippo signaling [5].
References:
[1] Efrat M, Rosenblat M, Mahmood S, et al. Di-oleoyl phosphatidylcholine (PC-18: 1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies[J]. Atherosclerosis, 2009, 202(2): 461-469.
[2] Caldo K M P, Shen W, Xu Y, et al. Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1‐catalyzed phosphorylation[J]. The Plant Journal, 2018, 96(2): 287-299.
[3] Leonenko Z V, Finot E, Ma H, et al. Investigation of temperature-induced phase transitions in DOPC and DPPC phospholipid bilayers using temperature-controlled scanning force microscopy[J]. Biophysical journal, 2004, 86(6): 3783-3793.
[4] Kandregula B, Narisepalli S, Chitkara D, et al. Exploration of lipid-based nanocarriers as drug delivery systems in diabetic foot ulcer[J]. Molecular Pharmaceutics, 2022, 19(7): 1977-1998.
[5] Tei R, Baskin J M. Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds[J]. Journal of Cell Biology, 2020, 219(3): e201907013.
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