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Chromenone 1

Catalog No.GC70882

Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator.

Products are for research use only. Not for human use. We do not sell to patients.

Chromenone 1 Chemical Structure

Cas No.: 1639929-29-5

Size Price Stock Qty
1 mg
$117.00
In stock
5 mg
$270.00
In stock
10 mg
$401.00
In stock
25 mg
$682.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.

Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts[1].

References:
[1]. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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