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Clodronate (sodium salt hydrate) (Synonyms: Clodronic acid)

Catalog No.GC43279

Clodronate (sodium salt hydrate) (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects.

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Clodronate (sodium salt hydrate) Chemical Structure

Cas No.: 88416-50-6

Size Price Stock Qty
50mg
$13.00
In stock
10mM (in 1mL Water)
$14.00
In stock
100mg
$21.00
In stock
250mg
$42.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description of Clodronate (sodium salt hydrate)

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.

Chemical Properties of Clodronate (sodium salt hydrate)

Cas No. 88416-50-6 SDF
Synonyms Clodronic acid
Canonical SMILES OP(C(Cl)(Cl)P(O)([O-])=O)([O-])=O.[Na+].[Na+].O.O.O.O
Formula CH2Cl2O6P2•2Na [4H2O] M.Wt 360.9
Solubility PBS (pH 7.2): 10 mg/ml Storage Store at 2-8°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Clodronate (sodium salt hydrate)

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1 mg 5 mg 10 mg
1 mM 2.7709 mL 13.8543 mL 27.7085 mL
5 mM 0.5542 mL 2.7709 mL 5.5417 mL
10 mM 0.2771 mL 1.3854 mL 2.7709 mL
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In vivo Formulation Calculator (Clear solution) of Clodronate (sodium salt hydrate)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 34 reference(s) in Google Scholar.)

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