D-Glucose-6-phosphate (sodium salt) (Synonyms: G6P, Sodium Glucose-6-Phosphate)

D-Glucose-6-phosphate (sodium salt) is an essential component of glucose metabolism. It is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or glucose-1-phosphate is converted by phosphoglucomutase, which is the first step in glycogen synthesis ^[1]. D-Glucose 6-Phosphate is located at the starting point of two major metabolic pathways: glycolysis and the pentose phosphate pathway ^[2]. D-Glucose 6-Phosphate can be converted to glycogen or starch and stored in cells ^[3]. D-Glucose 6-Phosphate can be used as a substrate to measure the activity of recombinant mannitol-1-phosphatase (M1Pase) ^[4]. D-Glucose 6-Phosphate can be used as a substrate to measure the specificity of SapM protein ^[5]. This product is the sodium salt form of D-Glucose 6-Phosphate, with a molecular formula of C6H12NaO9P and a molecular weight of 282.12.

References:
[1]Jang W, Gomer R H. Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum[J]. Eukaryotic cell, 2005, 4(1): 72-81.
[2]Litwack, Gerald .Chapter 6-Insulin and Sugars.Human Biochemistry. Academic Press.2018:131–160.
[3]Lal M A. Metabolism of storage carbohydrates[J]. Plant physiology, development and metabolism. Springer Nature, Singapore. Doi, 2018, 10: 978-981.
[4] Groisillier A, Tonon T. Determination of Recombinant Mannitol-1-phosphatase Activity from Ectocarpus sp[J]. Bio-protocol, 2016, 6(16): e1896-e1896.
[5]Fernandez-Soto P, Bruce A J E, Fielding A J, et al. Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs[J]. Scientific reports, 2019, 9(1): 10315.