Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2, (trifluoroacetate salt) (Synonyms: MMP Fluorogenic Substrate III) |
| Catalog No.GC47164 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3, and MMP-9.1 Upon enzymatic cleavage by MMP-1, MMP-2, MMP-3, or MMP-9 at the Gly-Leu site, EDANS is separated from the Dabcyl quencher and its fluorescence can be used to quantify MMP-1, MMP-2, MMP-3, and MMP-9 activity.1,2 EDANS displays excitation/emission maxima of 340/485 nm, respectively.
1.Beekman, B., Drijfhout, J.W., Bloemhoff, W., et al.Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological mediaFEBS Lett.390(2)221-225(1996) 2.Krismastuti, F.S.H., Pace, S., and Voelcker, N.H.Porous silicon resonant microcavity biosensor for matrix metalloproteinase detectionAdv. Funct. Mater.24(23)3639-3650(2014)
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