DALDA acetate |
| Catalog No.GC72209 |
DALDA acetate is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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DALDA acetate carrys a net positive charge (3+) at physiological pH and is thus hydrophilic and more polar than morphine[1].
DALDA acetate (0-7 nmol/rat; i.t.; once) shows antinociceptive and respiratory effects in rats[1].
DALDA acetate (0.1 and 1.0 μg/side; ICV; once) results in biphasic effects, with an initial suppression, an intermediate marked inhibition, followed by activation for horizontal movement, rearing and stereotypy times in rats[2].
References:
[1]. Shimoyama M, et al. Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1): 364-371.
[2]. Meyer ME, et al. DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities. Pharmacol Biochem Behav. 1995 May;51(1):149-51.
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