11-deoxy-11-methylene-15-keto Prostaglandin D2 (Synonyms: 11deoxy11methylene15keto PGD2) |
Katalog-Nr.GC41879 |
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2.
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Cas No.: 958759-75-6
Sample solution is provided at 25 µL, 10mM.
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor. However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2. This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2. 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.
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