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16,16-dimethyl Prostaglandin E1 (Synonyms: 16,16dimethyl PGE1)

Katalog-Nr.GC18777

16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1.

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16,16-dimethyl Prostaglandin E1 Chemische Struktur

Cas No.: 41692-15-3

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Sample solution is provided at 25 µL, 10mM.

Description of 16,16-dimethyl Prostaglandin E1

16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. It induces human vascular smooth muscle contractions in vitro. It is 2, 3, and 6 times more potent than PGF2α in contracting tracheal, bronchial, and bronchiolar smooth muscle, respectively.

Chemical Properties of 16,16-dimethyl Prostaglandin E1

Cas No. 41692-15-3 SDF
Überlieferungen 16,16dimethyl PGE1
Chemical Name 9-oxo-11α,15R-dihydroxy-16,16-dimethyl-prost-13E-en-1-oic acid
Canonical SMILES CCCCC(C)(C)C(O)\C=C\[C@H]1C(O)CC(=O)C1CCCCCCC(=O)O
Formula C22H38O5 M.Wt 382.5
Löslichkeit DMF`: >100 mg/ml (from PGE1),DMSO: >50 mg/ml (from PGE1),Ethanol: >50 mg/ml (from PGE1),PBS pH 7.2: >1.6 mg/ml (from PGE1) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 16,16-dimethyl Prostaglandin E1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.6144 mL 13.0719 mL 26.1438 mL
5 mM 0.5229 mL 2.6144 mL 5.2288 mL
10 mM 0.2614 mL 1.3072 mL 2.6144 mL
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In vivo Formulation Calculator (Clear solution) of 16,16-dimethyl Prostaglandin E1

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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