3-Phosphoglyceric acid |
| Katalog-Nr.GC70376 |
3-Phosphoglyceric acid ist ein metabolisches Zwischenprodukt sowohl in der Glykolyse als auch im Calvin-Zyklus.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 820-11-1
Sample solution is provided at 25 µL, 10mM.
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3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1].
3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1].
In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1].
References:
[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193.
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