5'-Methylthioadenosine-13C6 |
Katalog-Nr.GC71507 |
5'-Methylthioadenosine-13C6 ist das 13C-markierte 5'-Methylthiodenosin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2421187-73-5
Sample solution is provided at 25 µL, 10mM.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References:
[1]. Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.
[2]. Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.
[3]. Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.
[4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.
[5]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Average Rating: 5
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