6-Deoxy-8-O-methylrabelomycin (Synonyms: (-)-8-O-Methyltetrangomycin,MM 47755) |
| Katalog-Nr.GC91494 |
6-Deoxy-8-O-methylrabelomycin is an anthraquinone that has been found in Pseudonocardia with antiparasitic and antibiotic activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 117620-87-8
Sample solution is provided at 25 µL, 10mM.
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6-Deoxy-8-O-methylrabelomycin is an anthraquinone that has been found in Pseudonocardia with antiparasitic and antibiotic activities.[1],[2] It is active against the parasite P. berghei (IC50 = 18.5 µM) and the bacterium B. subtilis (MIC = 25 µg/ml) but does not induce cellular toxicity in HepG2 cells (IC50 = >100 µM).[1] 6-Deoxy-8-O-methylrabelomycin is also active against methicillin-resistant S. aureus (MRSA; IC50 = 48 µg/ml) and reduces MRSA production of the virulence factor staphyloxanthin (IC50 = 6 µg/ml).[2]
References:
[1].Carr, G., Derbyshire, E.R., Caldera, E., et al.Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.J. Nat. Prod.75(10)1806-1809(2012).
[2].Sakai, K., Koyama, N., Fukuda, T., et al.Search method for inhibitors of staphyloxanthin production by methicillin-resistant Staphylococcus aureusBiol. Pharm. Bull.35(1)48-53(2012).
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