8R(9S)-EET (Synonyms: 8R(9S)-epoxy-all-cis-5,11,14-Eicosatrienoic Acid,8R(9S)-EpETrE,8R(9S)-Epoxyeicosatrienoic Acid,8R(9S)-epoxy-5(Z),11(Z),14(Z)-ETrE,FA 20:4;O) |
| Katalog-Nr.GC91508 |
8R(9S)-EET is an oxylipin and a metabolite of arachidonic acid .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 129172-62-9
Sample solution is provided at 25 µL, 10mM.
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8R(9S)-EET is an oxylipin and a metabolite of arachidonic acid .1 It is formed via oxidation of arachidonic acid by the cytochrome P450 (CYP) isoform CYP2C11. 8R(9S)-EET induces relaxation of precontracted isolated dog epicardial arterioles (EC50 = 15 pM).2
References:
[1].Capdevila, J.H., Karara, A., Waxman, D.J., et al.Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenaseJ. Biol. Chem.265(19)10865-10871(1990).
[2].Zhang, Y., Oltman, C.L., Lu, T., et al.EET homologs potently dilate coronary microvessels and activate BKCa channelsAm. J. Physiol. Heart Circ. Physiol.280(6)H2430-H2440(2001).
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