α-Angelica lactone |
| Katalog-Nr.GC61980 |
α-Angelikalacton ist ein natÜrlich vorkommendes Antikarzinogen und ein vinyloges Nucleophil. α-Angelica-Lacton kann die chiralen δ-Amino γ,γ-disubstituierten Butenolid-Carbonylderivate ergeben und ein selektivrophiles Abfangen am γ-Kohlenstoff aufweisen. α-Angelikalacton Übt starke chemoprotektive Wirkungen durch selektive VerstÄrkung der Entgiftungsenzyme Glutathion-S-thansferase (GST) und UDP-Glucononosyltransferase (UGT) aus.
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Cas No.: 591-12-8
Sample solution is provided at 25 µL, 10mM.
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α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes[1][2][3][4].
[1]. W A Nijhoff, et al. Quantification of Induction of Rat Oesophageal, Gastric and Pancreatic Glutathione and Glutathione S-transferases by Dietary Anticarcinogens. Carcinogenesis. 1994 Sep;15(9):1769-72.
[2]. E M J van der Logt, et al. Induction of Rat Hepatic and Intestinal UDP-glucuronosyltransferases by Naturally Occurring Dietary Anticarcinogens. Carcinogenesis. 2003 Oct;24(10):1651-6.
[3]. Lin Zhou, et al. Catalytic Asymmetric Vinylogous Mannich-type (AVM) Reaction of Nonactivated α-Angelica Lactone. Org Lett. 2011 Jun 17;13(12):3056-9.
[4]. Jessica A Griswold, et al. Diastereoselective Organocatalytic Addition of α-Angelica Lactone to β-Halo-α-ketoesters. J Org Chem. 2017 Feb 17;82(4):2276-2280.
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