α-Hemolysin |
| Katalog-Nr.GC26215 |
lyophilized powder, Protein ~60 % by Lowry, ≥10,000 units/mg protein.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 94716-94-6
Sample solution is provided at 25 µL, 10mM.
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α-Hemolysin is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1].
References:
[1]. Robin R Craven, et al. Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS One. 2009 Oct 14;4(10):e7446.
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